Conjugates of methylene blue with γ-carboline derivatives as new multifunctional agents for the trea...
Conjugates of methylene blue with γ-carboline derivatives as new multifunctional agents for the treatment of neurodegenerative diseases
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Author / Creator
Bachurin, Sergey O. , Makhaeva, Galina F. , Shevtsova, Elena F. , Boltneva, Natalia P. , Kovaleva, Nadezhda V. , Lushchekina, Sofya V. , Rudakova, Elena V. , Dubova, Ludmila G. , Vinogradova, Daria V. , Sokolov, Vladimir B. , Aksinenko, Alexey Yu , Fisenko, Vladimir P. , Richardson, Rudy J. and Aliev, Gjumrakch
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
We studied the inhibitory activity of methylene blue (MB) γ-carbolines (gC) conjugates (MB-gCs) against human erythrocyte acetylcholinesterase (AChE), equine serum butyrylcholinesterase (BChE), and a structurally related enzyme, porcine liver carboxylesterase (CaE). In addition, we determined the ability of MB-gCs to bind to the peripheral anionic...
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Conjugates of methylene blue with γ-carboline derivatives as new multifunctional agents for the treatment of neurodegenerative diseases
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6424957
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6424957
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-019-41272-4
