Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangemen...
Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Cancer genomes are frequently characterized by numerical and structural chromosomal abnormalities. Here we integrated a centromere-specific inactivation approach with selection for a conditionally essential gene, a strategy termed CEN-SELECT, to systematically interrogate the structural landscape of mis-segregated chromosomes. We show that single-c...
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Full title
Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6441390
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6441390
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ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-019-0360-8
