ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells
ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells
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Author / Creator
Mohammed, Rebar N. , Wehenkel, Sophie C. , Galkina, Elena V. , Yates, Emma-Kate , Preece, Graham , Newman, Andrew , Watson, H. Angharad , Ohme, Julia , Bridgeman, John S. , Durairaj, Ruban R. P. , Moon, Owen R. , Ladell, Kristin , Miners, Kelly L. , Dolton, Garry , Troeberg, Linda , Kashiwagi, Masahide , Murphy, Gillian , Nagase, Hideaki , Price, David A. , Matthews, R. James , Knäuper, Vera and Ager, Ann
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
L-selectin on T-cells is best known as an adhesion molecule that supports recruitment of blood-borne naïve and central memory cells into lymph nodes. Proteolytic shedding of the ectodomain is thought to redirect activated T-cells from lymph nodes to sites of infection. However, we have shown that activated T-cells re-express L-selectin before lymph...
Alternative Titles
Full title
ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells
Authors, Artists and Contributors
Author / Creator
Wehenkel, Sophie C.
Galkina, Elena V.
Yates, Emma-Kate
Preece, Graham
Newman, Andrew
Watson, H. Angharad
Ohme, Julia
Bridgeman, John S.
Durairaj, Ruban R. P.
Moon, Owen R.
Ladell, Kristin
Miners, Kelly L.
Dolton, Garry
Troeberg, Linda
Kashiwagi, Masahide
Murphy, Gillian
Nagase, Hideaki
Price, David A.
Matthews, R. James
Knäuper, Vera
Ager, Ann
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6445073
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6445073
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-019-41811-z
