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Alcohol consumption increases susceptibility to pneumococcal pneumonia in a humanized murine HIV mod...

Alcohol consumption increases susceptibility to pneumococcal pneumonia in a humanized murine HIV mod...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6449221

Alcohol consumption increases susceptibility to pneumococcal pneumonia in a humanized murine HIV model mediated by intestinal dysbiosis

About this item

Full title

Alcohol consumption increases susceptibility to pneumococcal pneumonia in a humanized murine HIV model mediated by intestinal dysbiosis

Publisher

United States: Elsevier Inc

Journal title

Alcohol (Fayetteville, N.Y.), 2019-11, Vol.80, p.33-43

Language

English

Formats

Publication information

Publisher

United States: Elsevier Inc

More information

Scope and Contents

Contents

AbstractAlcohol use in persons living with HIV (PLWH) worsens the severity of bacterial pneumonia. However, the exact mechanism(s) by which this occurs remain ill-defined. We hypothesized that alcohol in the setting of HIV infection decreases Streptococcus pneumoniae clearance from the lung through mechanisms mediated by the gut microbiota. Humaniz...

Alternative Titles

Full title

Alcohol consumption increases susceptibility to pneumococcal pneumonia in a humanized murine HIV model mediated by intestinal dysbiosis

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6449221

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6449221

Other Identifiers

ISSN

0741-8329,1873-6823

E-ISSN

1873-6823

DOI

10.1016/j.alcohol.2018.08.012

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