Impact of novel NS5A resistance-associated substitutions of hepatitis C virus detected in treatment-...
Impact of novel NS5A resistance-associated substitutions of hepatitis C virus detected in treatment-experienced patients
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Author / Creator
Nitta, Sayuri , Asahina, Yasuhiro , Kato, Takanobu , Tsuchiya, Jun , Inoue-Shinomiya, Emi , Sato, Ayako , Tsunoda, Tomoyuki , Miyoshi, Masato , Kawai-Kitahata, Fukiko , Murakawa, Miyako , Itsui, Yasuhiro , Nakagawa, Mina , Azuma, Seishin , Kakinuma, Sei , Hikita, Hayato , Takehara, Tetsuo and Watanabe, Mamoru
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Resistance-associated substitutions (RASs) of hepatitis C virus (HCV) in the NS5A region impair the efficacy of NS5A inhibitors. In this study, we evaluated the characteristics of the novel RASs observed in treatment-failure patients, A92K and a deletion at P32 (P32del), and the susceptibility of viruses with these RASs to various anti-HCV reagents...
Alternative Titles
Full title
Impact of novel NS5A resistance-associated substitutions of hepatitis C virus detected in treatment-experienced patients
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6450881
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6450881
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-019-42114-z
