The human HOXA9 protein uses paralog-specific residues of the homeodomain to interact with TALE-clas...
The human HOXA9 protein uses paralog-specific residues of the homeodomain to interact with TALE-class cofactors
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
HOX proteins interact with PBX and MEIS cofactors, which belong to the TALE-class of homeodomain (HD)-containing transcription factors. Although the formation of HOX-PBX complexes depends on a unique conserved HOX motif called hexapeptide (HX), the additional presence of MEIS induces a remodeling of the interaction, leading to a global dispensabili...
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Full title
The human HOXA9 protein uses paralog-specific residues of the homeodomain to interact with TALE-class cofactors
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6450960
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6450960
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-019-42096-y
