ATP7A delivers copper to the lysyl oxidase family of enzymes and promotes tumorigenesis and metastas...
ATP7A delivers copper to the lysyl oxidase family of enzymes and promotes tumorigenesis and metastasis
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Lysyl oxidase (LOX) and LOX-like (LOXL) proteins are copperdependent metalloenzymes with well-documented roles in tumor metastasis and fibrotic diseases. The mechanism by which copper is delivered to these enzymes is poorly understood. In this study, we demonstrate that the copper transporter ATP7A is necessary for the activity of LOX and LOXL enzy...
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Full title
ATP7A delivers copper to the lysyl oxidase family of enzymes and promotes tumorigenesis and metastasis
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6452744
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6452744
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1817473116
