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Metabolic regulation of transcription through compartmentalized NAD + biosynthesis

Metabolic regulation of transcription through compartmentalized NAD + biosynthesis

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6465534

Metabolic regulation of transcription through compartmentalized NAD + biosynthesis

About this item

Full title

Metabolic regulation of transcription through compartmentalized NAD + biosynthesis

Publisher

United States: The American Association for the Advancement of Science

Journal title

Science (American Association for the Advancement of Science), 2018-05, Vol.360 (6389)

Language

English

Formats

Publication information

Publisher

United States: The American Association for the Advancement of Science

More information

Scope and Contents

Contents

NAD
(nicotinamide adenine dinucleotide in its oxidized state) is an essential molecule for a variety of physiological processes. It is synthesized in distinct subcellular compartments by three different synthases (NMNAT-1, -2, and -3). We found that compartmentalized NAD
synthesis by NMNATs integrates glucose metabolism and adipogenic transcr...

Alternative Titles

Full title

Metabolic regulation of transcription through compartmentalized NAD + biosynthesis

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6465534

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6465534

Other Identifiers

ISSN

0036-8075

E-ISSN

1095-9203

DOI

10.1126/science.aan5780

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