Gene expression differences between matched pairs of ovarian cancer patient tumors and patient-deriv...
Gene expression differences between matched pairs of ovarian cancer patient tumors and patient-derived xenografts
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
As patient derived xenograft (PDX) models are increasingly used for preclinical drug development, strategies to account for the nonhuman component of PDX RNA expression data are critical to its interpretation. A bioinformatics pipeline to separate donor tumor and mouse stroma transcriptome profiles was devised and tested. To examine the molecular f...
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Full title
Gene expression differences between matched pairs of ovarian cancer patient tumors and patient-derived xenografts
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6474864
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6474864
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-019-42680-2
