Discovery of selective activators of PRC2 mutant EED-I363M
Discovery of selective activators of PRC2 mutant EED-I363M
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Publisher
London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
Many common disease-causing mutations result in loss-of-function (LOF) of the proteins in which they occur. LOF mutations have proven recalcitrant to pharmacologic intervention, presenting a challenge for the development of targeted therapeutics. Polycomb repressive complex 2 (PRC2), which contains core subunits (EZH2, EED, and SUZ12), regulates ge...
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Full title
Discovery of selective activators of PRC2 mutant EED-I363M
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6484020
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6484020
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-019-43005-z
