Large-conductance Ca2+- and voltage-gated K⁺ channels form and break interactions with membrane lipi...
Large-conductance Ca2+- and voltage-gated K⁺ channels form and break interactions with membrane lipids during each gating cycle
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Washington: National Academy of Sciences
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Language
English
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Washington: National Academy of Sciences
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Membrane depolarization and intracellular Ca2+ promote activation of the large-conductance Ca2+- and voltage-gated (Slo1) big potassium (BK) channel. We examined the physical interactions that stabilize the closed and open conformations of the ion conduction gate of the human Slo1 channel using electrophysiological and computational approaches. The...
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Full title
Large-conductance Ca2+- and voltage-gated K⁺ channels form and break interactions with membrane lipids during each gating cycle
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6486743
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6486743
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1901381116
