Effect of a phosphodiesterase-5A (PDE5A) gene polymorphism on response to sildenafil therapy in cani...
Effect of a phosphodiesterase-5A (PDE5A) gene polymorphism on response to sildenafil therapy in canine pulmonary hypertension
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Pulmonary hypertension (PH) is a common clinical condition associated with morbidity and mortality in both humans and dogs. Sildenafil, a phosphodiesterase-5 (PDE5) inhibitor causing accumulation of cGMP, is frequently used for treatment of PH. The authors previously reported a
PDE5A
:E90K polymorphism in dogs that results in lower basal cycl...
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Full title
Effect of a phosphodiesterase-5A (PDE5A) gene polymorphism on response to sildenafil therapy in canine pulmonary hypertension
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6499771
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6499771
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-019-43318-z
