Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming
Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Silencing of the somatic cell type-specific genes is a critical yet poorly understood step in reprogramming. To uncover pathways that maintain cell identity, we performed a reprogramming screen using inhibitors of chromatin factors. Here, we identify acetyl-lysine competitive inhibitors targeting the bromodomains of coactivators CREB (cyclic-AMP re...
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Full title
Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6504645
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6504645
Other Identifiers
ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/s41589-019-0264-z
