Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction
Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction
About this item
Full title
Author / Creator
Liu, Xindong , Wang, Yun , Lu, Huiping , Li, Jing , Yan, Xiaowei , Xiao, Minglu , Hao, Jing , Alekseev, Andrei , Khong, Hiep , Chen, Tenghui , Huang, Rui , Wu, Jin , Zhao, Qiwen , Wu, Qi , Xu, Senlin , Wang, Xiaohu , Jin, Wei , Yu, Shicang , Wang, Yan , Wei, Lai , Wang, Aibo , Zhong, Bo , Ni, Ling , Liu, Xiaolong , Nurieva, Roza , Ye, Lilin , Tian, Qiang , Bian, Xiu-Wu and Dong, Chen
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
T cells become dysfunctional when they encounter self antigens or are exposed to chronic infection or to the tumour microenvironment
1
. The function of T cells is tightly regulated by a combinational co-stimulatory signal, and dominance of negative co-stimulation results in T cell dysfunction
2
. However, the molecular mechanisms that...
Alternative Titles
Full title
Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction
Authors, Artists and Contributors
Author / Creator
Wang, Yun
Lu, Huiping
Li, Jing
Yan, Xiaowei
Xiao, Minglu
Hao, Jing
Alekseev, Andrei
Khong, Hiep
Chen, Tenghui
Huang, Rui
Wu, Jin
Zhao, Qiwen
Wu, Qi
Xu, Senlin
Wang, Xiaohu
Jin, Wei
Yu, Shicang
Wang, Yan
Wei, Lai
Wang, Aibo
Zhong, Bo
Ni, Ling
Liu, Xiaolong
Nurieva, Roza
Ye, Lilin
Tian, Qiang
Bian, Xiu-Wu
Dong, Chen
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6507425
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6507425
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-019-0979-8
