C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic...
C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A
About this item
Full title
Author / Creator
Moens, Thomas G. , Niccoli, Teresa , Wilson, Katherine M. , Atilano, Magda L. , Birsa, Nicol , Gittings, Lauren M. , Holbling, Benedikt V. , Dyson, Miranda C. , Thoeng, Annora , Neeves, Jacob , Glaria, Idoia , Yu, Lu , Bussmann, Julia , Storkebaum, Erik , Pardo, Mercedes , Choudhary, Jyoti S. , Fratta, Pietro , Partridge, Linda and Isaacs, Adrian M.
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
Formats
Publication information
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Subjects
More information
Scope and Contents
Contents
A GGGGCC hexanucleotide repeat expansion within the
C9orf72
gene is the most common genetic cause of both amyotrophic lateral sclerosis and frontotemporal dementia. Sense and antisense repeat-containing transcripts undergo repeat-associated non-AUG-initiated translation to produce five dipeptide proteins (DPRs). The polyGR and polyPR DPRs are...
Alternative Titles
Full title
C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A
Authors, Artists and Contributors
Author / Creator
Niccoli, Teresa
Wilson, Katherine M.
Atilano, Magda L.
Birsa, Nicol
Gittings, Lauren M.
Holbling, Benedikt V.
Dyson, Miranda C.
Thoeng, Annora
Neeves, Jacob
Glaria, Idoia
Yu, Lu
Bussmann, Julia
Storkebaum, Erik
Pardo, Mercedes
Choudhary, Jyoti S.
Fratta, Pietro
Partridge, Linda
Isaacs, Adrian M.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6514073
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6514073
Other Identifiers
ISSN
0001-6322
E-ISSN
1432-0533
DOI
10.1007/s00401-018-1946-4
