Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death
Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death
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Author / Creator
Orning, Pontus , Weng, Dan , Starheim, Kristian , Ratner, Dmitry , Best, Zachary , Lee, Bettina , Brooks, Alexandria , Xia, Shiyu , Wu, Hao , Kelliher, Michelle A , Berger, Scott B , Gough, Peter J , Bertin, John , Proulx, Megan M , Goguen, Jon D , Kayagaki, Nobuhiko , Fitzgerald, Katherine A and Lien, Egil
Publisher
United States: The American Association for the Advancement of Science
Journal title
Language
English
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Publisher
United States: The American Association for the Advancement of Science
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Scope and Contents
Contents
Limited proteolysis of gasdermin D (GSDMD) generates an N-terminal pore-forming fragment that controls pyroptosis in macrophages. GSDMD is processed via inflammasome-activated caspase-1 or -11. It is currently unknown whether macrophage GSDMD can be processed by other mechanisms. Here, we describe an additional pathway controlling GSDMD processing....
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Full title
Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6522129
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6522129
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aau2818
