Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity
Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity
About this item
Full title
Author / Creator
Zhang, Yong-Jie , Guo, Lin , Gonzales, Patrick K. , Gendron, Tania F. , Wu, Yanwei , Jansen-West, Karen , O’Raw, Aliesha D. , Pickles, Sarah R. , Prudencio, Mercedes , Carlomagno, Yari , Gachechiladze, Mariam A. , Ludwig, Connor , Tian, Ruilin , Chew, Jeannie , DeTure, Michael , Lin, Wen-Lang , Tong, Jimei , Daughrity, Lillian M. , Yue, Mei , Song, Yuping , Andersen, Jonathan W. , Castanedes-Casey, Monica , Kurti, Aishe , Datta, Abhishek , Antognetti, Giovanna , McCampbell, Alexander , Rademakers, Rosa , Oskarsson, Björn , Dickson, Dennis W. , Kampmann, Martin , Ward, Michael E. , Fryer, John D. , Link, Christopher D. , Shorter, James and Petrucelli, Leonard
Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
A repeat expansion in the chromosome 9 open reading frame 72 (
C9orf72
) gene is the most common known cause of two neurodegenerative diseases: frontotemporal dementia and amyotrophic lateral sclerosis. This expansion leads to the abnormal production of proteins of repeating dipeptides, but their contribution to disease pathogenesis remains u...
Alternative Titles
Full title
Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity
Authors, Artists and Contributors
Author / Creator
Guo, Lin
Gonzales, Patrick K.
Gendron, Tania F.
Wu, Yanwei
Jansen-West, Karen
O’Raw, Aliesha D.
Pickles, Sarah R.
Prudencio, Mercedes
Carlomagno, Yari
Gachechiladze, Mariam A.
Ludwig, Connor
Tian, Ruilin
Chew, Jeannie
DeTure, Michael
Lin, Wen-Lang
Tong, Jimei
Daughrity, Lillian M.
Yue, Mei
Song, Yuping
Andersen, Jonathan W.
Castanedes-Casey, Monica
Kurti, Aishe
Datta, Abhishek
Antognetti, Giovanna
McCampbell, Alexander
Rademakers, Rosa
Oskarsson, Björn
Dickson, Dennis W.
Kampmann, Martin
Ward, Michael E.
Fryer, John D.
Link, Christopher D.
Shorter, James
Petrucelli, Leonard
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6524780
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6524780
Other Identifiers
ISSN
0036-8075,1095-9203
E-ISSN
1095-9203
DOI
10.1126/science.aav2606
