The macroH2A1.2 histone variant links ATRX loss to alternative telomere lengthening
The macroH2A1.2 histone variant links ATRX loss to alternative telomere lengthening
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Publisher
New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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The growth of telomerase-deficient cancers depends on the alternative lengthening of telomeres (ALT), a homology-directed telomere-maintenance pathway. ALT telomeres exhibit a unique chromatin environment and generally lack the nucleosome remodeler ATRX, pointing to an epigenetic basis for ALT. Recently, we identified a protective role for the ATRX...
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Full title
The macroH2A1.2 histone variant links ATRX loss to alternative telomere lengthening
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6537592
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6537592
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/s41594-019-0192-3
