Arrestin-β-1 Physically Scaffolds TSH and IGF1 Receptors to Enable Crosstalk
Arrestin-β-1 Physically Scaffolds TSH and IGF1 Receptors to Enable Crosstalk
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Author / Creator
Publisher
Washington, DC: Endocrine Society
Journal title
Language
English
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Publisher
Washington, DC: Endocrine Society
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Abstract
Endogenously expressed TSH receptors (TSHRs) on orbital fibroblasts of patients with Graves ophthalmopathy (GO) use crosstalk with IGF1 receptors (IGF1R) to synergistically stimulate secretion of hyaluronan (HA), a major component of GO pathology. We previously showed crosstalk occurred upstream of mitogen-activated protein kinase (ERK)...
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Full title
Arrestin-β-1 Physically Scaffolds TSH and IGF1 Receptors to Enable Crosstalk
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6542485
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6542485
Other Identifiers
ISSN
1945-7170,0013-7227
E-ISSN
1945-7170
DOI
10.1210/en.2019-00055
