A transcriptome-wide association study of high grade serous epithelial ovarian cancer identifies nov...
A transcriptome-wide association study of high grade serous epithelial ovarian cancer identifies novel susceptibility genes and splice variants
About this item
Full title
Author / Creator
Gusev, Alexander , Lawrenson, Kate , Lin, Xianzhi , Lyra, Paulo C. , Kar, Siddhartha , Vavra, Kevin C. , Segato, Felipe , Fonseca, Marcos A.S. , Lee, Janet M , Pejovic, Tanya , Liu, Gang , Karlan, Beth Y. , Freedman, Matthew L. , Noushmehr, Houtan , Monteiro, Alvaro N. , Pharoah, Paul D.P. , Pasaniuc, Bogdan and Gayther, Simon A.
Journal title
Language
English
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Scope and Contents
Contents
We sought to identify susceptibility genes for high-grade serous ovarian cancer (HGSOC) by performing a transcriptome-wide association study (TWAS) of gene expression and splice junction usage in HGSOC-relevant tissue types (
N
= 2,169) and the largest GWAS available for HGSOC (
N
= 13,037 cases/40,941 controls). We identified 25 TWAS s...
Alternative Titles
Full title
A transcriptome-wide association study of high grade serous epithelial ovarian cancer identifies novel susceptibility genes and splice variants
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6548545
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6548545
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-019-0395-x
