Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors
Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Base editing requires that the target sequence satisfy the protospacer adjacent motif requirement of the Cas9 domain and that the target nucleotide be located within the editing window of the base editor. To increase the targeting scope of base editors, we engineered six optimized adenine base editors (ABEmax variants) that use SpCas9 variants comp...
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Full title
Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6551276
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6551276
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ISSN
1087-0156,1546-1696
E-ISSN
1546-1696
DOI
10.1038/s41587-019-0134-y
