SUN-350 Sterol-O-Acyl Transferase 1 Protein Expression Alone Is Not Sufficient to Predict Response t...
SUN-350 Sterol-O-Acyl Transferase 1 Protein Expression Alone Is Not Sufficient to Predict Response to Mitotane Treatment in Adrenocortical Carcinoma
About this item
Full title
Author / Creator
Weigand, Isabel , Altieri, Barbara , Ferreira, Amanda , Basile, Vittoria , Landwehr, Laura-Sophie , Ronchi, Cristina , Schreiner, Jochen , Megerle, Felix , Berruti, Alfredo , Canu, Letizia , Volante, Marco , Paiva, Isabel , Della Casa, Silvia , Sbiera, Silviu , Fassnacht, Martin , Fragoso, Maria , Terzolo, Massimo and Kroiss, Matthias
Publisher
Washington, DC: Endocrine Society
Journal title
Language
English
Formats
Publication information
Publisher
Washington, DC: Endocrine Society
Subjects
More information
Scope and Contents
Contents
Background:
Objective response rate to mitotane in advanced ACC is only ~20% and adverse drug effects are frequent and potentially serious. Markers of treatment response are not established. We have previously discovered that mitotane is an inhibitor of sterol-O-Acyl transferase 1 (SOAT1) which leads to depletion of cholesterol esters, endoplasm...
Alternative Titles
Full title
SUN-350 Sterol-O-Acyl Transferase 1 Protein Expression Alone Is Not Sufficient to Predict Response to Mitotane Treatment in Adrenocortical Carcinoma
Authors, Artists and Contributors
Author / Creator
Altieri, Barbara
Ferreira, Amanda
Basile, Vittoria
Landwehr, Laura-Sophie
Ronchi, Cristina
Schreiner, Jochen
Megerle, Felix
Berruti, Alfredo
Canu, Letizia
Volante, Marco
Paiva, Isabel
Della Casa, Silvia
Sbiera, Silviu
Fassnacht, Martin
Fragoso, Maria
Terzolo, Massimo
Kroiss, Matthias
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6553006
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6553006
Other Identifiers
ISSN
2472-1972
E-ISSN
2472-1972
DOI
10.1210/js.2019-SUN-350
