Multiple SCN5A variant enhancers modulate its cardiac gene expression and the QT interval
Multiple SCN5A variant enhancers modulate its cardiac gene expression and the QT interval
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
The rationale for genome-wide association study (GWAS) results is sequence variation in cis-regulatory elements (CREs) modulating a target gene’s expression as the major cause of trait variation. To understand the complete molecular landscape of one of these GWAS loci, we performed in vitro reporter screens in cardiomyocyte cell lines for CREs over...
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Full title
Multiple SCN5A variant enhancers modulate its cardiac gene expression and the QT interval
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6561183
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6561183
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1808734116
