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Elasticity of individual protocadherin 15 molecules implicates tip links as the gating springs for h...

Elasticity of individual protocadherin 15 molecules implicates tip links as the gating springs for h...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6561218

Elasticity of individual protocadherin 15 molecules implicates tip links as the gating springs for hearing

About this item

Full title

Elasticity of individual protocadherin 15 molecules implicates tip links as the gating springs for hearing

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2019-05, Vol.116 (22), p.11048-11056

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Hair cells, the sensory receptors of the inner ear, respond to mechanical forces originating from sounds and accelerations. An essential feature of each hair cell is an array of filamentous tip links, consisting of the proteins protocadherin 15 (PCDH15) and cadherin 23 (CDH23), whose tension is thought to directly gate the cell’s transduction chann...

Alternative Titles

Full title

Elasticity of individual protocadherin 15 molecules implicates tip links as the gating springs for hearing

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6561218

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6561218

Other Identifiers

ISSN

0027-8424,1091-6490

E-ISSN

1091-6490

DOI

10.1073/pnas.1902163116

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