The levels of the NMDA receptor co-agonist D-serine are reduced in the substantia nigra of MPTP-lesi...
The levels of the NMDA receptor co-agonist D-serine are reduced in the substantia nigra of MPTP-lesioned macaques and in the cerebrospinal fluid of Parkinson’s disease patients
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Author / Creator
Nuzzo, Tommaso , Punzo, Daniela , Devoto, Paola , Rosini, Elena , Paciotti, Silvia , Sacchi, Silvia , Li, Qin , Thiolat, Marie-Laure , Véga, Celine , Carella, Massimo , Carta, Manolo , Gardoni, Fabrizio , Calabresi, Paolo , Pollegioni, Loredano , Bezard, Erwan , Parnetti, Lucilla , Errico, Francesco and Usiello, Alessandro
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Dysfunction of NMDA receptor (NMDAR)-mediated transmission is supposed to contribute to the motor and non-motor symptoms of Parkinson’s Disease (PD), and to L-DOPA-induced dyskinesia. Besides the main agonist L-glutamate, two other amino acids in the atypical D-configuration, D-serine and D-aspartate, activate NMDARs. In the present work, we invest...
Alternative Titles
Full title
The levels of the NMDA receptor co-agonist D-serine are reduced in the substantia nigra of MPTP-lesioned macaques and in the cerebrospinal fluid of Parkinson’s disease patients
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6586824
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6586824
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-019-45419-1
