XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity
XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity
About this item
Full title
Author / Creator
Johansson, Linda C. , Stauch, Benjamin , McCorvy, John D. , Han, Gye Won , Patel, Nilkanth , Huang, Xi-Ping , Batyuk, Alexander , Gati, Cornelius , Slocum, Samuel T. , Li, Chufeng , Grandner, Jessica M. , Hao, Shuming , Olsen, Reid H. J. , Tribo, Alexandra R. , Zaare, Sahba , Zhu, Lan , Zatsepin, Nadia A. , Weierstall, Uwe , Yous, Saïd , Stevens, Raymond C. , Liu, Wei , Roth, Bryan L. , Katritch, Vsevolod , Cherezov, Vadim and SLAC National Accelerator Laboratory (SLAC), Menlo Park, CA (United States)
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The human MT
1
and MT
2
melatonin receptors
1
,
2
are G-protein-coupled receptors (GPCRs) that help to regulate circadian rhythm and sleep patterns
3
. Drug development efforts have targeted both receptors for the treatment of insomnia, circadian rhythm and mood disorders, and cancer
3
, and MT
2
has also b...
Alternative Titles
Full title
XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity
Authors, Artists and Contributors
Author / Creator
Stauch, Benjamin
McCorvy, John D.
Han, Gye Won
Patel, Nilkanth
Huang, Xi-Ping
Batyuk, Alexander
Gati, Cornelius
Slocum, Samuel T.
Li, Chufeng
Grandner, Jessica M.
Hao, Shuming
Olsen, Reid H. J.
Tribo, Alexandra R.
Zaare, Sahba
Zhu, Lan
Zatsepin, Nadia A.
Weierstall, Uwe
Yous, Saïd
Stevens, Raymond C.
Liu, Wei
Roth, Bryan L.
Katritch, Vsevolod
Cherezov, Vadim
SLAC National Accelerator Laboratory (SLAC), Menlo Park, CA (United States)
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6589158
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6589158
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-019-1144-0
