NRF2/ARE pathway negatively regulates BACE1 expression and ameliorates cognitive deficits in mouse A...
NRF2/ARE pathway negatively regulates BACE1 expression and ameliorates cognitive deficits in mouse Alzheimer’s models
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Author / Creator
Bahn, Gahee , Park, Jong-Sung , Yun, Ui Jeong , Lee, Yoon Jee , Choi, Yuri , Park, Jin Su , Baek, Seung Hyun , Choi, Bo Youn , Cho, Yoon Suk , Kim, Hark Kyun , Han, Jihoon , Sul, Jae Hoon , Baik, Sang-Ha , Lim, Jinhwan , Wakabayashi, Nobunao , Bae, Soo Han , Han, Jeung-Whan , Arumugam, Thiruma V. , Mattson, Mark P. and Jo, Dong-Gyu
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Contents
BACE1 is the rate-limiting enzyme for amyloid-β peptides (Aβ) generation, a key event in the pathogenesis of Alzheimer’s disease (AD). By an unknown mechanism, levels of BACE1 and a BACE1 mRNA-stabilizing antisense RNA (BACE1-AS) are elevated in the brains of AD patients, implicating that dysregulation of BACE1 expression plays an important role in...
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Full title
NRF2/ARE pathway negatively regulates BACE1 expression and ameliorates cognitive deficits in mouse Alzheimer’s models
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6589670
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6589670
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1819541116
