Harnessing the anti-cancer natural product nimbolide for targeted protein degradation
Harnessing the anti-cancer natural product nimbolide for targeted protein degradation
About this item
Full title
Author / Creator
Spradlin, Jessica N. , Hu, Xirui , Ward, Carl C. , Brittain, Scott M. , Jones, Michael D. , Ou, Lisha , To, Milton , Proudfoot, Andrew , Ornelas, Elizabeth , Woldegiorgis, Mikias , Olzmann, James A. , Bussiere, Dirksen E. , Thomas, Jason R. , Tallarico, John A. , McKenna, Jeffrey M. , Schirle, Markus , Maimone, Thomas J. and Nomura, Daniel K.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Nimbolide, a terpenoid natural product derived from the Neem tree, impairs cancer pathogenicity; however, the direct targets and mechanisms by which nimbolide exerts its effects are poorly understood. Here, we used activity-based protein profiling (ABPP) chemoproteomic platforms to discover that nimbolide reacts with a novel functional cysteine cru...
Alternative Titles
Full title
Harnessing the anti-cancer natural product nimbolide for targeted protein degradation
Authors, Artists and Contributors
Author / Creator
Hu, Xirui
Ward, Carl C.
Brittain, Scott M.
Jones, Michael D.
Ou, Lisha
To, Milton
Proudfoot, Andrew
Ornelas, Elizabeth
Woldegiorgis, Mikias
Olzmann, James A.
Bussiere, Dirksen E.
Thomas, Jason R.
Tallarico, John A.
McKenna, Jeffrey M.
Schirle, Markus
Maimone, Thomas J.
Nomura, Daniel K.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6592714
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6592714
Other Identifiers
ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/s41589-019-0304-8
