Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreas...
Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The antioxidant tempol reduces obesity in mice. Here we show that tempol alters the gut microbiome by preferentially reducing the genus
Lactobacillus
and its bile salt hydrolase (BSH) activity leading to the accumulation of intestinal tauro-β-muricholic acid (T-β-MCA). T-β-MCA is an farnesoid X receptor (FXR) nuclear receptor antagonist, whic...
Alternative Titles
Full title
Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6595219
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6595219
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms3384
