Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling
Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling
About this item
Full title
Author / Creator
Gunner, Georgia , Cheadle, Lucas , Johnson, Kasey M. , Ayata, Pinar , Badimon, Ana , Mondo, Erica , Nagy, M. Aurel , Liu, Liwang , Bemiller, Shane M. , Kim, Ki-Wook , Lira, Sergio A. , Lamb, Bruce T. , Tapper, Andrew R. , Ransohoff, Richard M. , Greenberg, Michael E. , Schaefer, Anne and Schafer, Dorothy P.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Microglia rapidly respond to changes in neural activity and inflammation to regulate synaptic connectivity. The extracellular signals, particularly neuron-derived molecules, that drive these microglial functions at synapses remain a key open question. Here we show that whisker lesioning, known to dampen cortical activity, induces microglia-mediated...
Alternative Titles
Full title
Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6596419
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6596419
Other Identifiers
ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/s41593-019-0419-y
