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Drp1S600 phosphorylation regulates mitochondrial fission and progression of nephropathy in diabetic...

Drp1S600 phosphorylation regulates mitochondrial fission and progression of nephropathy in diabetic...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6597204

Drp1S600 phosphorylation regulates mitochondrial fission and progression of nephropathy in diabetic mice

About this item

Full title

Drp1S600 phosphorylation regulates mitochondrial fission and progression of nephropathy in diabetic mice

Publisher

United States: American Society for Clinical Investigation

Journal title

The Journal of clinical investigation, 2019-07, Vol.129 (7), p.2807-2823

Language

English

Formats

Publication information

Publisher

United States: American Society for Clinical Investigation

More information

Scope and Contents

Contents

Phosphorylation of Dynamin-related protein1 (Drp1) represents an important regulatory mechanism for mitochondrial fission. Here we established the role of Drp1 Serine 600 (S600) phosphorylation on mitochondrial fission in vivo, and assessed the functional consequences of targeted elimination of the Drp1S600 phosphorylation site in progression of di...

Alternative Titles

Full title

Drp1S600 phosphorylation regulates mitochondrial fission and progression of nephropathy in diabetic mice

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6597204

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6597204

Other Identifiers

ISSN

0021-9738

E-ISSN

1558-8238

DOI

10.1172/JCI127277

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