Matrine improves skeletal muscle atrophy by inhibiting E3 ubiquitin ligases and activating the Akt/m...
Matrine improves skeletal muscle atrophy by inhibiting E3 ubiquitin ligases and activating the Akt/mTOR/FoxO3α signaling pathway in C2C12 myotubes and mice
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Full title
Author / Creator
Chen, Li , Chen, Linlin , Wan, Lili , Huo, Yan , Huang, Jinlu , Li, Jie , Lu, Jin , Xin, Bo , Yang, Quanjun and Guo, Cheng
Publisher
Greece: Spandidos Publications UK Ltd
Journal title
Language
English
Formats
Publication information
Publisher
Greece: Spandidos Publications UK Ltd
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Scope and Contents
Contents
Skeletal muscle wasting is a feature of cancer cachexia that increases patient morbidity and mortality. Matrine, the main bioactive component of Sophora flavescens, has been approved for the prevention and therapy of cancer cachexia in China. However, to the best of our knowledge, its mechanism in improving muscle wasting remains unknown. The prese...
Alternative Titles
Full title
Matrine improves skeletal muscle atrophy by inhibiting E3 ubiquitin ligases and activating the Akt/mTOR/FoxO3α signaling pathway in C2C12 myotubes and mice
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6610044
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6610044
Other Identifiers
ISSN
1021-335X
E-ISSN
1791-2431
DOI
10.3892/or.2019.7205
