Multiparametric rapid screening of neuronal process pathology for drug target identification in HSP...
Multiparametric rapid screening of neuronal process pathology for drug target identification in HSP patient-specific neurons
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Axonal degeneration is a key pathology of neurodegenerative diseases, including hereditary spastic paraplegia (HSP), a disorder characterized by spasticity in the lower limbs. Treatments for HSP and other neurodegenerative diseases are mainly symptomatic. While iPSC-derived neurons are valuable for drug discovery and target identification, these ap...
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Full title
Multiparametric rapid screening of neuronal process pathology for drug target identification in HSP patient-specific neurons
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6610147
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6610147
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-019-45246-4
