ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway
ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway
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Author / Creator
Chu, Bo , Kon, Ning , Chen, Delin , Li, Tongyuan , Liu, Tong , Jiang, Le , Song, Shujuan , Tavana, Omid and Gu, Wei
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
It is well established that ferroptosis is primarily controlled by glutathione peroxidase 4 (GPX4). Surprisingly, we observed that p53 activation modulates ferroptotic responses without apparent effects on GPX4 function. Instead, ALOX12 inactivation diminishes p53-mediated ferroptosis induced by reactive oxygen species stress and abrogates p53-depe...
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Full title
ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6624840
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6624840
Other Identifiers
ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/s41556-019-0305-6
