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Structure-guided examination of the mechanogating mechanism of PIEZO2

Structure-guided examination of the mechanogating mechanism of PIEZO2

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6628815

Structure-guided examination of the mechanogating mechanism of PIEZO2

About this item

Full title

Structure-guided examination of the mechanogating mechanism of PIEZO2

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2019-07, Vol.116 (28), p.14260-14269

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Piezo channels are mechanically activated ion channels that confer mechanosensitivity to a variety of different cell types. Piezos oligomerize as propeller-shaped homotrimers that are thought to locally curve the membrane into spherical domes that project into the cell. While several studies have identified domains and amino acids that control impo...

Alternative Titles

Full title

Structure-guided examination of the mechanogating mechanism of PIEZO2

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6628815

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6628815

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1905985116

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