Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition
Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Autophagy is a lysosomal degradation pathway that eliminates aggregated proteins and damaged organelles to maintain cellular homeostasis. A major route for activating autophagy involves inhibition of the mTORC1 kinase, but current mTORC1-targeting compounds do not allow complete and selective mTORC1 blockade. Here, we have coupled screening of a co...
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Full title
Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6641988
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6641988
Other Identifiers
ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/s41589-019-0308-4
