Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endotheli...
Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1
About this item
Full title
Author / Creator
Yousef, Hanadie , Czupalla, Cathrin J. , Lee, Davis , Chen, Michelle B. , Burke, Ashley N. , Zera, Kristy A. , Zandstra, Judith , Berber, Elisabeth , Lehallier, Benoit , Mathur, Vidhu , Nair, Ramesh V. , Bonanno, Liana N. , Yang, Andrew C. , Peterson, Todd , Hadeiba, Husein , Merkel, Taylor , Körbelin, Jakob , Schwaninger, Markus , Buckwalter, Marion S. , Quake, Stephen R. , Butcher, Eugene C. and Wyss-Coray, Tony
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
An aged circulatory environment can activate microglia, reduce neural precursor cell activity and impair cognition in mice. We hypothesized that brain endothelial cells (BECs) mediate at least some of these effects. We observe that BECs in the aged mouse hippocampus express an inflammatory transcriptional profile with focal upregulation of vascular...
Alternative Titles
Full title
Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1
Authors, Artists and Contributors
Author / Creator
Czupalla, Cathrin J.
Lee, Davis
Chen, Michelle B.
Burke, Ashley N.
Zera, Kristy A.
Zandstra, Judith
Berber, Elisabeth
Lehallier, Benoit
Mathur, Vidhu
Nair, Ramesh V.
Bonanno, Liana N.
Yang, Andrew C.
Peterson, Todd
Hadeiba, Husein
Merkel, Taylor
Körbelin, Jakob
Schwaninger, Markus
Buckwalter, Marion S.
Quake, Stephen R.
Butcher, Eugene C.
Wyss-Coray, Tony
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6642642
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6642642
Other Identifiers
ISSN
1078-8956,1546-170X
E-ISSN
1546-170X
DOI
10.1038/s41591-019-0440-4
