Calreticulin Ins5 and Del52 mutations impair unfolded protein and oxidative stress responses in K562...
Calreticulin Ins5 and Del52 mutations impair unfolded protein and oxidative stress responses in K562 cells expressing CALR mutants
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Author / Creator
Salati, Simona , Genovese, Elena , Carretta, Chiara , Zini, Roberta , Bartalucci, Niccolò , Prudente, Zelia , Pennucci, Valentina , Ruberti, Samantha , Rossi, Chiara , Rontauroli, Sebastiano , Enzo, Elena , Calabresi, Laura , Balliu, Manjola , Mannarelli, Carmela , Bianchi, Elisa , Guglielmelli, Paola , Tagliafico, Enrico , Vannucchi, Alessandro M. and Manfredini, Rossella
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Somatic mutations of calreticulin (CALR) have been described in approximately 60–80% of JAK2 and MPL unmutated Essential Thrombocythemia and Primary Myelofibrosis patients. CALR is an endoplasmic reticulum (ER) chaperone responsible for proper protein folding and calcium retention. Recent data demonstrated that the TPO receptor (MPL) is essential f...
Alternative Titles
Full title
Calreticulin Ins5 and Del52 mutations impair unfolded protein and oxidative stress responses in K562 cells expressing CALR mutants
Authors, Artists and Contributors
Author / Creator
Genovese, Elena
Carretta, Chiara
Zini, Roberta
Bartalucci, Niccolò
Prudente, Zelia
Pennucci, Valentina
Ruberti, Samantha
Rossi, Chiara
Rontauroli, Sebastiano
Enzo, Elena
Calabresi, Laura
Balliu, Manjola
Mannarelli, Carmela
Bianchi, Elisa
Guglielmelli, Paola
Tagliafico, Enrico
Vannucchi, Alessandro M.
Manfredini, Rossella
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6646313
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6646313
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-019-46843-z
