Thymic regulatory T cells arise via two distinct developmental programs
Thymic regulatory T cells arise via two distinct developmental programs
About this item
Full title
Author / Creator
Owen, David L. , Mahmud, Shawn A. , Sjaastad, Louisa E. , Williams, Jason B. , Spanier, Justin A. , Simeonov, Dimitre R. , Ruscher, Roland , Huang, Weishan , Proekt, Irina , Miller, Corey N. , Hekim, Can , Jeschke, Jonathan C. , Aggarwal, Praful , Broeckel, Ulrich , LaRue, Rebecca S. , Henzler, Christine M. , Alegre, Maria-Luisa , Anderson, Mark S. , August, Avery , Marson, Alexander , Zheng, Ye , Williams, Calvin B. and Farrar, Michael A.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
The developmental programs that generate a broad repertoire of regulatory T cells (T
reg
cells) able to respond to both self antigens and non-self antigens remain unclear. Here we found that mature T
reg
cells were generated through two distinct developmental programs involving CD25
+
T
reg
cell progenitors (CD25
+
T
Alternative Titles
Full title
Thymic regulatory T cells arise via two distinct developmental programs
Authors, Artists and Contributors
Author / Creator
Mahmud, Shawn A.
Sjaastad, Louisa E.
Williams, Jason B.
Spanier, Justin A.
Simeonov, Dimitre R.
Ruscher, Roland
Huang, Weishan
Proekt, Irina
Miller, Corey N.
Hekim, Can
Jeschke, Jonathan C.
Aggarwal, Praful
Broeckel, Ulrich
LaRue, Rebecca S.
Henzler, Christine M.
Alegre, Maria-Luisa
Anderson, Mark S.
August, Avery
Marson, Alexander
Zheng, Ye
Williams, Calvin B.
Farrar, Michael A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6650268
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6650268
Other Identifiers
ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/s41590-018-0289-6
