Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis
Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis
About this item
Full title
Author / Creator
Sher, Falak , Hossain, Mir , Seruggia, Davide , Schoonenberg, Vivien A. C. , Yao, Qiuming , Cifani, Paolo , Dassama, Laura M. K. , Cole, Mitchel A. , Ren, Chunyan , Vinjamur, Divya S. , Macias-Trevino, Claudio , Luk, Kevin , McGuckin, Connor , Schupp, Patrick G. , Canver, Matthew C. , Kurita, Ryo , Nakamura, Yukio , Fujiwara, Yuko , Wolfe, Scot A. , Pinello, Luca , Maeda, Takahiro , Kentsis, Alex , Orkin, Stuart H. and Bauer, Daniel E.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Developmental silencing of fetal globins serves as both a paradigm of spatiotemporal gene regulation and an opportunity for therapeutic intervention of β-hemoglobinopathy. The nucleosome remodeling and deacetylase (NuRD) chromatin complex participates in γ-globin repression. We used pooled CRISPR screening to disrupt NuRD protein coding sequences c...
Alternative Titles
Full title
Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis
Authors, Artists and Contributors
Author / Creator
Hossain, Mir
Seruggia, Davide
Schoonenberg, Vivien A. C.
Yao, Qiuming
Cifani, Paolo
Dassama, Laura M. K.
Cole, Mitchel A.
Ren, Chunyan
Vinjamur, Divya S.
Macias-Trevino, Claudio
Luk, Kevin
McGuckin, Connor
Schupp, Patrick G.
Canver, Matthew C.
Kurita, Ryo
Nakamura, Yukio
Fujiwara, Yuko
Wolfe, Scot A.
Pinello, Luca
Maeda, Takahiro
Kentsis, Alex
Orkin, Stuart H.
Bauer, Daniel E.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6650275
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6650275
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-019-0453-4
