Simulated microgravity increases polyploid giant cancer cells and nuclear localization of YAP
Simulated microgravity increases polyploid giant cancer cells and nuclear localization of YAP
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Physical cues are vital in determining cellular fate in cancer.
In vitro
3D culture do not replicate forces present
in vivo
. These forces including tumor interstitial fluid pressure and matrix stiffness behave as switches in differentiation and metastasis, which are intricate features of cancer stem cells (CSCs). Gravity determines the...
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Full title
Simulated microgravity increases polyploid giant cancer cells and nuclear localization of YAP
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6650394
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6650394
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-019-47116-5
