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pHERV-W envelope protein fuels microglial cell-dependent damage of myelinated axons in multiple scle...

pHERV-W envelope protein fuels microglial cell-dependent damage of myelinated axons in multiple scle...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6660731

pHERV-W envelope protein fuels microglial cell-dependent damage of myelinated axons in multiple sclerosis

About this item

Full title

pHERV-W envelope protein fuels microglial cell-dependent damage of myelinated axons in multiple sclerosis

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2019-07, Vol.116 (30), p.15216-15225

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Axonal degeneration is central to clinical disability and disease progression in multiple sclerosis (MS). Myeloid cells such as brain-resident microglia and blood-borne monocytes are thought to be critically involved in this degenerative process. However, the exact underlying mechanisms have still not been clarified. We have previously demonstrated...

Alternative Titles

Full title

pHERV-W envelope protein fuels microglial cell-dependent damage of myelinated axons in multiple sclerosis

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6660731

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6660731

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1901283116

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