The AMPK–Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome
The AMPK–Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome
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Author / Creator
Lee, Seung Baek , Kim, Jung Jin , Han, Sang-Ah , Fan, Yingfang , Guo, Li-Sha , Aziz, Khaled , Nowsheen, Somaira , Kim, Sung Sun , Park, Seon-Young , Luo, Qifeng , Chung, Jin Ook , Choi, Sung Il , Aziz, Asef , Yin, Ping , Tong, Seo-Yun , Fiesel, Fabienne C. , Springer, Wolfdieter , Zhang, Jin-San and Lou, Zhenkun
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
The receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 play important roles in necroptosis that are closely linked to the inflammatory response. Although the activation of necroptosis is well characterized, the mechanism that tunes down necroptosis is largely unknown. Here we find that Parkin (also known as PARK2), an E3 ubiquiti...
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Full title
The AMPK–Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6679774
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6679774
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ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/s41556-019-0356-8
