Microglial Depletion with Clodronate Liposomes Increases Proinflammatory Cytokine Levels, Induces As...
Microglial Depletion with Clodronate Liposomes Increases Proinflammatory Cytokine Levels, Induces Astrocyte Activation, and Damages Blood Vessel Integrity
About this item
Full title
Author / Creator
Han, Xiaoning , Li, Qian , Lan, Xi , EL-Mufti, Leena , Ren, Honglei and Wang, Jian
Publisher
New York: Springer US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Springer US
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More information
Scope and Contents
Contents
Investigators are increasingly interested in using microglial depletion to study the role of microglia under pathologic conditions. Liposome-encapsulated clodronate is commonly used to eliminate macrophage populations because it causes functionally irreversible inhibition and apoptosis once phagocytized by macrophages. Recent studies have shown tha...
Alternative Titles
Full title
Microglial Depletion with Clodronate Liposomes Increases Proinflammatory Cytokine Levels, Induces Astrocyte Activation, and Damages Blood Vessel Integrity
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6684378
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6684378
Other Identifiers
ISSN
0893-7648
E-ISSN
1559-1182
DOI
10.1007/s12035-019-1502-9
