Preoperative administration of the 5-HT4 receptor agonist prucalopride reduces intestinal inflammati...
Preoperative administration of the 5-HT4 receptor agonist prucalopride reduces intestinal inflammation and shortens postoperative ileus via cholinergic enteric neurons
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Author / Creator
Stakenborg, Nathalie , Labeeuw, Evelien , Gomez-Pinilla, Pedro J , De Schepper, Sebastiaan , Aerts, Raymond , Goverse, Gera , Farro, Giovanna , Appeltans, Iris , Meroni, Elisa , Stakenborg, Michelle , Viola, Maria Francesca , Gonzalez-Dominguez, Erika , Bosmans, Goele , Alpizar, Yeranddy A , Wolthuis, Albert , D’Hoore, Andre , Van Beek, Kim , Verheijden, Simon , Verhaegen, Marleen , Derua, Rita , Waelkens, Etienne , Moretti, Milena , Gotti, Cecilia , Augustijns, Patrick , Talavera, Karel , Vanden Berghe, Pieter , Matteoli, Gianluca and Boeckxstaens, Guy E
Publisher
England: BMJ Publishing Group Ltd and British Society of Gastroenterology
Journal title
Language
English
Formats
Publication information
Publisher
England: BMJ Publishing Group Ltd and British Society of Gastroenterology
Subjects
More information
Scope and Contents
Contents
ObjectivesVagus nerve stimulation (VNS), most likely via enteric neurons, prevents postoperative ileus (POI) by reducing activation of alpha7 nicotinic receptor (α7nAChR) positive muscularis macrophages (mMφ) and dampening surgery-induced intestinal inflammation. Here, we evaluated if 5-HT4 receptor (5-HT4R) agonist prucalopride can mimic this effe...
Alternative Titles
Full title
Preoperative administration of the 5-HT4 receptor agonist prucalopride reduces intestinal inflammation and shortens postoperative ileus via cholinergic enteric neurons
Authors, Artists and Contributors
Author / Creator
Labeeuw, Evelien
Gomez-Pinilla, Pedro J
De Schepper, Sebastiaan
Aerts, Raymond
Goverse, Gera
Farro, Giovanna
Appeltans, Iris
Meroni, Elisa
Stakenborg, Michelle
Viola, Maria Francesca
Gonzalez-Dominguez, Erika
Bosmans, Goele
Alpizar, Yeranddy A
Wolthuis, Albert
D’Hoore, Andre
Van Beek, Kim
Verheijden, Simon
Verhaegen, Marleen
Derua, Rita
Waelkens, Etienne
Moretti, Milena
Gotti, Cecilia
Augustijns, Patrick
Talavera, Karel
Vanden Berghe, Pieter
Matteoli, Gianluca
Boeckxstaens, Guy E
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6691854
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6691854
Other Identifiers
ISSN
0017-5749
E-ISSN
1468-3288
DOI
10.1136/gutjnl-2018-317263
