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Structural Insights into Metabotropic Glutamate Receptor Activation

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Structural Insights into Metabotropic Glutamate Receptor Activation

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6709600

Structural Insights into Metabotropic Glutamate Receptor Activation

About this item

Full title

Structural Insights into Metabotropic Glutamate Receptor Activation

Author / Creator

Koehl, Antoine , Hu, Hongli , Feng, Dan , Sun, Bingfa , Zhang, Yan , Robertson, Michael J , Chu, Matthew , Kobilka, Tong Sun , Pardon, Els , Steyaert, Jan , Tarrasch, Jeffrey , Dutta, Somnath , Fonseca, Rasmus , Weis, William I , Mathiesen, Jesper M , Skiniotis, Georgios and Kobilka, Brian K

Journal title

Nature (London), 2019-01, Vol.566 (7742), p.79-84

Language

English

Formats

Articles

More information

Scope and Contents

Contents

Metabotropic glutamate receptors are Family C G protein coupled receptors that form obligate dimers and possess extracellular ligand binding Venus flytrap (VFT) domains, which are linked via cysteine rich domains (CRDs) to their 7-transmembrane (7TM) domain. Spectroscopic studies show that signaling is a dynamic process, with large scale conformati...

Alternative Titles

Full title

Structural Insights into Metabotropic Glutamate Receptor Activation

Authors, Artists and Contributors

Author / Creator

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6709600

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6709600

Other Identifiers

ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/s41586-019-0881-4

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