Smoothened stimulation by membrane sterols drives Hedgehog pathway activity
Smoothened stimulation by membrane sterols drives Hedgehog pathway activity
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Author / Creator
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS) , Deshpande, Ishan , Liang, Jiahao , Hedeen, Danielle , Roberts, Kelsey J. , Zhang, Yunxiao , Ha, Betty , Latorraca, Naomi R. , Faust, Bryan , Dror, Ron O. , Beachy, Philip A. , Myers, Benjamin R. and Manglik, Aashish
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Hedgehog signalling is fundamental to embryonic development and postnatal tissue regeneration
1
. Aberrant postnatal Hedgehog signalling leads to several malignancies, including basal cell carcinoma and paediatric medulloblastoma
2
. Hedgehog proteins bind to and inhibit the transmembrane cholesterol transporter Patched-1 (PTCH1), which...
Alternative Titles
Full title
Smoothened stimulation by membrane sterols drives Hedgehog pathway activity
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Author / Creator
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6709672
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6709672
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-019-1355-4
