EZH2 cooperates with E2F1 to stimulate expression of genes involved in adrenocortical carcinoma aggr...
EZH2 cooperates with E2F1 to stimulate expression of genes involved in adrenocortical carcinoma aggressiveness
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Author / Creator
Tabbal, Houda , Septier, Amandine , Mathieu, Mickael , Drelon, Coralie , Rodriguez, Stéphanie , Djari, Cyril , Batisse-Lignier, Marie , Tauveron, Igor , Pointud, Jean-Christophe , Sahut-Barnola, Isabelle , Ragazzon, Bruno , Assié, Guillaume , Bertherat, Jérôme , Lefrançois-Martinez, Anne-Marie , Martinez, Antoine and Val, Pierre
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Background
EZH2 is overexpressed and associated with poor prognosis in adrenocortical carcinoma (ACC) and its inhibition reduces growth and aggressiveness of ACC cells in culture. Although EZH2 was identified as the methyltransferase that deposits the repressive H3K27me3 histone mark, it can cooperate with transcription factors to stimulate gene...
Alternative Titles
Full title
EZH2 cooperates with E2F1 to stimulate expression of genes involved in adrenocortical carcinoma aggressiveness
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6738105
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6738105
Other Identifiers
ISSN
0007-0920
E-ISSN
1532-1827
DOI
10.1038/s41416-019-0538-y
