Molecular evolution of the switch for progesterone and spironolactone from mineralocorticoid recepto...
Molecular evolution of the switch for progesterone and spironolactone from mineralocorticoid receptor agonist to antagonist
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
The mineralocorticoid receptor (MR) is highly conserved across vertebrate evolution. In terrestrial vertebrates, the MR mediates sodium homeostasis by aldosterone and also acts as a receptor for cortisol. Although the MR is present in fish, they lack aldosterone. The MR binds progesterone and spironolactone as antagonists in human MR but as agonist...
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Full title
Molecular evolution of the switch for progesterone and spironolactone from mineralocorticoid receptor agonist to antagonist
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6744879
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6744879
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ISSN
0027-8424,1091-6490
E-ISSN
1091-6490
DOI
10.1073/pnas.1903172116
