Plakophilin-2 Haploinsufficiency Causes Calcium Handling Deficits and Modulates the Cardiac Response...
Plakophilin-2 Haploinsufficiency Causes Calcium Handling Deficits and Modulates the Cardiac Response Towards Stress
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Author / Creator
van Opbergen, Chantal J M , Noorman, Maartje , Pfenniger, Anna , Copier, Jaël S , Vermij, Sarah H , Li, Zhen , van der Nagel, Roel , Zhang, Mingliang , de Bakker, Jacques M T , Glass, Aaron M , Mohler, Peter J , Taffet, Steven M , Vos, Marc A , van Rijen, Harold V M , Delmar, Mario and van Veen, Toon A B
Publisher
Switzerland: MDPI AG
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Language
English
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Publisher
Switzerland: MDPI AG
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Contents
Human variants in plakophilin-2 (PKP2) associate with most cases of familial arrhythmogenic cardiomyopathy (ACM). Recent studies show that PKP2 not only maintains intercellular coupling, but also regulates transcription of genes involved in Ca
cycling and cardiac rhythm. ACM penetrance is low and it remains uncertain, which genetic and environme...
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Full title
Plakophilin-2 Haploinsufficiency Causes Calcium Handling Deficits and Modulates the Cardiac Response Towards Stress
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6747156
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6747156
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ISSN
1422-0067,1661-6596
E-ISSN
1422-0067
DOI
10.3390/ijms20174076
